Clinical evidence for delayed chloroform poisoning
by
Thorpe CM, Spence AA.
University Department of Anaesthesia,
University of Edinburgh,
Edinburgh Royal Infirmary.
Br J Anaesth. 1997 Sep;79(3):402-9

ABSTRACT

From its introduction in 1847, chloroform proved to be a potent anaesthetic agent and over the next 50 yr its use became widespread. However, in 1912 the Committee on Anaesthesia of the American Medical Association stated that they were concerned with the occurrence of delayed chloroform poisoning in a number of cases. This conclusion was based on case reports and experimental animal data. However, subsequent studies and reported series of chloroform anaesthesia in humans have suggested a lower incidence of clinically significant liver injury. In this article we have investigated this discrepancy by analysing the published clinical data relating chloroform anaesthesia to liver damage.

People
Chloroform
Anaesthesia
Nitrous oxide
Horace Wells
William Morton
Obstetric anaesthesia
Molecular mechanisms
'My beloved chloroform'
'The secularisation of pain'
TRPC5 calcium ion channels
Acetylcholine/nicotinic receptors
Obstetric anaesthesia/John Snow

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