Drug interactions in anaesthesia
by
Vuyk J.
Department of Anaesthesiology,
University Medical Center,
Leiden, The Netherlands.
Minerva Anestesiol. 1999 May;65(5):215-8

ABSTRACT

Anaesthesia is nowadays seldom accomplished by a single agent because no single agent is able to provide all components of anaesthesia without seriously compromising haemodynamic and/or respiratory function, reducing operating conditions, or postponing postoperative recovery. Because of the small therapeutic window a detailed characterisation of the concentration-effect relationships of anaesthetic agents is required to allow a proper selection of the various intravenous agents and the combinations thereof to an optimal therapeutic pharmacological effect in the absence of significant side effects. During the past decade, for propofol and the various opioids fentanyl, alfentanil, sufentanil, and remifentanil considerable progress has been made in the characterisation of the pharmacokinetics and pharmacodynamics of these agents and of the combinations thereof. This manuscript describes the pharmacokinetic and dynamic interactions between these agents and the determination of optimal concentrations that assure adequate anaesthesia and a rapid return of recovery.

People
Opioids
Anaesthesia
Inhaled anaesthetics
Obstetric anaesthesia
Chloroform anaesthesia
A thalamocortical switch?
History of anaesthesia apparatus
Consciousness, anaesthesia and anaesthetics
Anaesthesia: mutants in yeast, nematodes, fruit flies and mice

Refs
HOME
HedWeb
Future Opioids
BLTC Research
Paradise-Engineering
The Hedonistic Imperative
MDMA: Utopian Pharmacology

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family